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Resveratrol, a polyphenolic compound, acts as a bidentate ligand that chelates copper ions via its 4-keto and 5-hydroxy groups, forming stable planar complexes that preferentially accumulate in hypoxic tumor microenvironments [114]

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When IgG auto-Abs bind to a cell-surface target, they can activate complement or immune cell-mediated inflammatory responses directed against non-pathogenic tissue [20, 131]

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